Projects with our
1. Department of Physiology
Together with the department of
physiology of the LUMC, we study the
effect of mutations in the P/Q-type calcium channel on the function of the
neuromuscular junction. This research group studies electrophysiology of this
synaps in various diseases including Myastenic Gravis, LEMS.
The principal investigators are Dr.
and Dr. Peter Molenaar.
2. Department of Neurology
Patients with the auto-immune disorder Lambert-Eaton Myastenic
Syndrome (LEMS) have antibodies directed against P/Q-type channels. We are
currently mapping epitopes that are recognized by antisera.
The principal investigator is Dr. Jan Verschuuren
clinical studies of epilepsy:
A large study has been initiated
to collect sporadic epilepsy patents as well as epilepsy families. With
this material both clinical and genetic studies are being performed.
Dr. R. R. Frants, Prof Dr. O. F. Brouwer
PhD student involved: