BCLC-study: Histopathology of Ovarian Cancer in BRCA1 And BRCA2 Carriers

Coordinator Sunil Lakhani (London, UK) 
Aim To define the histopathological characteristics of ovarian cancer developing in BRCA1 and BRCA2 carriers.
Calls for Ovarian cancer tissues (paraffin-embedded) or unstained sections.
Status Data call circulated Summer 1998 (reminder Spring 1999); Deadline for material submission is August 1, 1999.


We invite you to participate in a review of the histopathology of ovarian cancer in BRCA1 and BRCA2 carriers, under the auspices of the breast cancer linkage consortium. The organising of the review will be similar to the review of the pathology of hereditary breast cancer. Sunil R. Lakhani has agreed to organise the sectioning of blocks and the review process. Once all the slides have been obtained, an independent panel of expert pathologists will be invited to review them, blindly, together with a set of age-matched sporadics. This review will take place early 1999. Dr David Lowe from St. Bartholomew's Hospital, London, UK, has agreed to be one of the pathologists, but you are invited to suggest other ovarian cancer specialist Pathologist who may be interested in reviewing this unique resource.

Material to be collected

If you would like to participate in this collaborative study, you can do so by either:

  1. Sending paraffin blocks from ovarian cancer cases in known BRCA1/2 families, or other familial cases, to Sunil in London. If necessary, the Consortium can support you to send someone to London with the samples. Blocks will be cut at UCH and be returned to the contributing pathologist as soon as possible.
  2. Sending sections to Sunil, including the following:

Details of the pedigree and mutation status (if not in the existing BCLC database already), and a copy of the pathology report, should also be sent. The unstained slides will be kept as a resource for future BCLC studies.


If you wish to participate in this study, please contact Sunil as soon as possible to indicate approximately how many samples you may have and how you could send material. Sunil now has a histopath technician working with him to organise and coordinate the study for a fixed period of 5 months (till sept). So if you are thinking of contributing material, now is the time to do it, but in any case before August 1, 1999 


Dr. Sunil R Lakhani
Senior Lecturer & Consultant
Department of Histopathology
University College London Medical School
Rockefeller Building
University Street
London WC1E 6JJ
Tel: (+44) 0171 209 6019
Fax: (+44) 0171 387 3674
Email: s.lakhani@ucl.ac.uk

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Last updated: May, 1999