is generally hypothesized that the partial deletion of the subtelomeric
D4Z4 repeat array causes the transcriptional deregulation of one or more
genes nearby by a mechanism similar to position effect variegation
(PEV). To obtain more evidence for this hypothesis, we are studying
epigenetic modifications of this subtelomere such as CpG methylation. We
are also studying proteins known to play a role in PEV, often making use
of llama-derived heavy chain phage display
antibody fragments (More information: Silvère van der Maarel, Ph.D.