Introduction
Diagnosis
Research
Genotype - phenotype
Deletion mechanism
Chromatin structure
Animal models
Proteomics
Positions available
Student training
Selected reading
Support
Useful links
Personnel
Contact us
Home

 

Last updated:

July 2001






 

 

 

 

 


 

Facioscapulohumeral muscular dystrophy

chromatin studies

 

It is generally hypothesized that the partial deletion of the subtelomeric D4Z4 repeat array causes the transcriptional deregulation of one or more genes nearby by a mechanism similar to position effect variegation (PEV). To obtain more evidence for this hypothesis, we are studying epigenetic modifications of this subtelomere such as CpG methylation. We are also studying proteins known to play a role in PEV, often making use of llama-derived heavy chain phage display antibody fragments (More information: Silvère van der Maarel, Ph.D. E-mail: maarel@lumc.nl).