Unclassified variants in BRCA2 in the Dutch population

This table was generated from our database on 18-03-2002. We will continue to add references to this database and post updates on this site regularly.

Gene

Exon

Nt

Base Change

Codon

AA Change

Designation

In BIC?

Times found

BRCA2

3

353

A to G

42

Tyr to Cys

Y42C

Ja

2

BRCA2

6

332

-12 A to G

IVS5-12A>G (BRCA2)

Nee

1

BRCA2

9

667

-17 G to T

IVS8 -17G>T

Nee

1

BRCA2

10

1059

T to G

277

Asn to Lys

N277K

Ja

1

BRCA2

10

1379

C to T

384

Ser to Phe

S384F

Ja

1

BRCA2

10

1570

C to T

448

Arg to Cys

R448C

Ja

1

BRCA2

10

1623

A to C

465

Val to Val

1623A>C (V465V)

Ja

1

BRCA2

10

1742

T to C

505

Ile to Thr

I505T

Ja

1

BRCA2

10

2020

A to G

598

Thr to Ala

T598A

Ja

3

BRCA2

10

2117

C to T

630

Thr to Ile

T630I

Ja

1

BRCA2

10

2137

+22 del T

IVS10+22delT

Nee

6

BRCA2

11

2166

C to T

646

Ser to Ser

2166C/T (S646S)

Ja

1

BRCA2

11

2908

G to A

894

Val to Ile

V894I

Ja

2

BRCA2

11

3014

T to C

929

Leu to Ser

L929S

Ja

1

BRCA2

11

3031

G to A

935

Asp to Asn

D935N

Ja

1

BRCA2

11

4296

G to A

1356

Leu to Leu

4296G>A (L1356L)

Ja

1

BRCA2

11

4437

T to A

1403

Thr to Thr

4437T/A (T1403T)

Nee

1

BRCA2

11

4486

G to A

1420

Asp to Tyr

D1420Y (G>A)

Nee

1

BRCA2

11

4798

T to G

1523

Phe to Val

F1523V

Nee

1

BRCA2

11

4813

G to A

1529

Gly to Arg

G1529R

Ja

1

BRCA2

11

5780

T to G

1851

Ile to Ser

I1851S

Nee

1

BRCA2

11

6328

C to T

2034

Arg to Cys

R2034C

Ja

1

BRCA2

13

7172

T to G

2315

Ile to Arg

I2315R

Nee

1

BRCA2

14

7238

C to T

2337

Thr to Ile

T2337I

Nee

1

BRCA2

14

7245

G to C

2339

Lys to Asn

K2339N

Ja

1

BRCA2

14

7423

A to C

2399

Thr to Pro

7423A/C (T2399P)

Nee

1

BRCA2

14

7547

A to G

2440

His to Arg

H2440R

Ja

1

BRCA2

15

7845

+18 T to G

IVS15+18T>G

Nee

1

BRCA2

17

8034

-15 T to C

IVS16-15T>C

Nee

2

BRCA2

18

8206

T to G

2660

Tyr to Asp

Y2660D

Ja

2

BRCA2

18

8360

G to A

2712

Gly to Ala

D2712K

Nee

1

BRCA2

18

8377

G to T

2717

Ala to Ser

A2717S

Ja

4

BRCA2

18

8410

G to A

2728

Val to Ile

V2728I

Ja

4

BRCA2

18

8471

G to A

2748

Gly to Asp

G2748D

Ja

1

BRCA2

18

8518

G to A

2763

Ala to Thr

A2763T

Nee

2

BRCA2

20

8795

A to C

2856

Glu to Ala

E2856A

Ja

2

BRCA2

24

9382

C to T

3052

Arg to Trp

R3052W

Nee

2

BRCA2

24

9446

A to G

3073

Asp to Gly

D3073G

Nee

1

BRCA2

25

9485

-16 T to C

IVS24-16T>C

Ja

6

BRCA2

27

10462

A to G

3412

Ile to Val

I3412V

Ja

1

Gene	Exon	Nt	Base Change	Codon	AA Change	Designation	In BIC?	Times found
BRCA2	3	353	A to G	42	Tyr to Cys	Y42C	Ja	2
BRCA2	6	332	-12 A to G			IVS5-12A>G (BRCA2)	Nee	1
BRCA2	9	667	-17 G to T			IVS8 -17G>T	Nee	1
BRCA2	10	1059	T to G	277	Asn to Lys	N277K	Ja	1
BRCA2	10	1379	C to T	384	Ser to Phe	S384F	Ja	1
BRCA2	10	1570	C to T	448	Arg to Cys	R448C	Ja	1
BRCA2	10	1623	A to C	465	Val to Val	1623A>C (V465V)	Ja	1
BRCA2	10	1742	T to C	505	Ile to Thr	I505T	Ja	1
BRCA2	10	2020	A to G	598	Thr to Ala	T598A	Ja	3
BRCA2	10	2117	C to T	630	Thr to Ile	T630I	Ja	1
BRCA2	10	2137	+22 del T			IVS10+22delT	Nee	6
BRCA2	11	2166	C to T	646	Ser to Ser	2166C/T (S646S)	Ja	1
BRCA2	11	2908	G to A	894	Val to Ile	V894I	Ja	2
BRCA2	11	3014	T to C	929	Leu to Ser	L929S	Ja	1
BRCA2	11	3031	G to A	935	Asp to Asn	D935N	Ja	1
BRCA2	11	4296	G to A	1356	Leu to Leu	4296G>A (L1356L)	Ja	1
BRCA2	11	4437	T to A	1403	Thr to Thr	4437T/A (T1403T)	Nee	1
BRCA2	11	4486	G to A	1420	Asp to Tyr	D1420Y (G>A)	Nee	1
BRCA2	11	4798	T to G	1523	Phe to Val	F1523V	Nee	1
BRCA2	11	4813	G to A	1529	Gly to Arg	G1529R	Ja	1
BRCA2	11	5780	T to G	1851	Ile to Ser	I1851S	Nee	1
BRCA2	11	6328	C to T	2034	Arg to Cys	R2034C	Ja	1
BRCA2	13	7172	T to G	2315	Ile to Arg	I2315R	Nee	1
BRCA2	14	7238	C to T	2337	Thr to Ile	T2337I	Nee	1
BRCA2	14	7245	G to C	2339	Lys to Asn	K2339N	Ja	1
BRCA2	14	7423	A to C	2399	Thr to Pro	7423A/C (T2399P)	Nee	1
BRCA2	14	7547	A to G	2440	His to Arg	H2440R	Ja	1
BRCA2	15	7845	+18 T to G			IVS15+18T>G	Nee	1
BRCA2	17	8034	-15 T to C			IVS16-15T>C	Nee	2
BRCA2	18	8206	T to G	2660	Tyr to Asp	Y2660D	Ja	2
BRCA2	18	8360	G to A	2712	Gly to Ala	D2712K	Nee	1
BRCA2	18	8377	G to T	2717	Ala to Ser	A2717S	Ja	4
BRCA2	18	8410	G to A	2728	Val to Ile	V2728I	Ja	4
BRCA2	18	8471	G to A	2748	Gly to Asp	G2748D	Ja	1
BRCA2	18	8518	G to A	2763	Ala to Thr	A2763T	Nee	2
BRCA2	20	8795	A to C	2856	Glu to Ala	E2856A	Ja	2
BRCA2	24	9382	C to T	3052	Arg to Trp	R3052W	Nee	2
BRCA2	24	9446	A to G	3073	Asp to Gly	D3073G	Nee	1
BRCA2	25	9485	-16 T to C			IVS24-16T>C	Ja	6
BRCA2	27	10462	A to G	3412	Ile to Val	I3412V	Ja	1