BRCA1 other cancers risk

RISKS OF CANCER OTHER THAN BREAST AND OVARIAN CANCER IN 17q-LINKED FAMILIES

Cancer site	Carriers (n=464)^a		Non- carriers (n=221)		Unknown (n=642)		Estimated RR in carriers	One-sided P-value
Cancer site	Obs	Exp	Obs	Exp	Obs	Exp	Estimated RR in carriers	One-sided P-value
Colon	7	2.22	2	1.30	10	3.28	4.11 (2.36-7.15)	0.002
Prostate	7	1.61	0	0.80	6	3.56	3.33 (1.78-6.20)	0.006
Other^b	4	0.67	2	0.42	1	1.02	4.21	0.04

^aNumber of person-years of follow-up.
^bThe significant excess of other cancers could not be attributed to any one site.
Obs = observed; Exp = expected (Rates from the SEER program of the National Cancer Institute were used to obtain expected numbers for the USA studies, and England and Wales rates were used for the UK and European studies).
RR = relative risk

Taken from Ford et al. (1994). Data represent cancer incidence in 33 families, each containing at least 4 individuals with ovarian or breast cancer diagnosed before age 60, and each having a posterior probability of linkage to BRCA1 of at least 90%. There was no excess risk for, amongst others, cancers of the oesophagus, stomach, liver, pancreas, larynx, lung, bone, cervix, testis, bladder, kidney, brain, thyroid.