GENETIC HETEROGENEITY ANALYSIS OF BREAST CANCER FAMILIES

FAMILY GROUP NUMBER OF FAMILIES PROPORTION OF LINKED FAMILIES
Total Tested for
BRCA1		 Mutation
positive		 BRCA1BRCA2Other
ALL FAMILIES 237 180 64 0.52
(0.42-0.62)		 0.32
(0.22-0.43)		 0.16
(0.06-0.28)
MALE BREAST CANCER 26 14 2 0.16
(0.02-0.48)		 0.76
(0.43-0.97)		 0.08
(0.00-0.44)
FEMALE BREAST CANCER ONLY:
Overall 117 82 16 0.26
(0.13-0.42)		 0.32
(0.17-0.50)		 0.42
(0.21-0.62)
4-5 cases at age <60 years 83 63 11 0.28
(0.11-0.50)		 0.05
(0.00-0.29)		 0.67
(0.35-0.89)
6+ cases at age <60 years 34 19 5 0.21
(0.08-0.42)		 0.60
(0.34-0.83)		 0.19
(0.01-0.45)
BREAST-OVARIAN CANCER, NO MALES:
Overall 94 84 46 0.81
(0.68-0.91)		 0.14
(0.05-0.26)		 0.05
(0.00-0.16)
One ovarian cancer 42 39 20 0.69
(0.50-0.86)		 0.21
(0.06-0.40)		 0.10
(0.00-0.28)
2+ ovarian cancers 52 45 26 0.91
(0.76-0.99)		 0.09
(0.01-0.24)		 0.00
(0.00-0.11)

Taken from Ford et al. (1998). Data represent results from heterogeneity analysis under the CASH model incorporating BRCA1 mutation data.