Christa L. Tanganyika-de Winter, BSc.

Christa de Winter is Research Technician in the DMD Genetic Therapy Group at the Human Genetics Department (LUMC) since November 2003. Her Analyse paper won the Anna Wichersprijs for best Analyse paper in 2007-2008.

Publication list

Nellist, M., Goedbloed, M.A., de Winter, C.L., Verhaaf, B., Jankie A., Reuser, A.J., van den Ouweland, A.M., van der Sluijs, P. and Halley, (D.J. 2002) Identification and characterization of the interaction between tuberin and 14-3-3zeta. J Biol Chem 277, 39417-24.

Aartsma-Rus,A., De Winter,C.L., Janson,A.A., Kaman,W.E., van Ommen,G.J., Den Dunnen,J.T., and van Deutekom,J.C. (2005) Functional analysis of 114 exon-internal AONs for targeted DMD exon skipping: indication for steric hindrance of SR protein binding sites. Oligonucleotides., 15, 284-297.

Aartsma-Rus,A., Janson,A.A., Heemskerk,J.A., De Winter,C.L., van Ommen,G.J., and van Deutekom,J.C. (2006) Therapeutic modulation of DMD splicing by blocking exonic splicing enhancer sites with antisense oligonucleotides. Ann.N.Y.Acad.Sci., 1082, 74-76.

De Winter, C.L. and Aartsma-Rus, A. (2007) RNA-therapie voor de ziekte van Duchenne: Minder is meer. Analyse 07: 192-196. (Anna Wichersprijs for best paper in 2007-2008).
 

Aartsma-Rus A, van Vliet L, Hirschi M, Janson, A.A., Heemskerk, J.A. De Winter, C.L. et al. (2008) Guidelines for antisense oligonucleotide design and insight in splice modulating mechanisms. Mol Ther ; epub 23 Sept

Van Vliet L, de Winter CL, van Deutekom JCT....and Aartsma-Rus A (2008) Assessment of the feasibility of exon 45-55 multiexon skipping for Duchenne muscular dystrophy. BMC Med Genet, 9:105

Heemskerk JA, de Winter CL, De Kimpe S...and Aartsma-Rus A (2009) In vivo comparison of 2'O-methyl-PS and morpholino antisense oligonucleotides for DMD exon skipping. J Gene Med ; 11:257-66

Heemskerk JA, de Winter CL, van Ommen G-J, van Deutekom JCT and Aartsma-Rus A: Development of antisense-mediated exon skipping as a treatment for Duchenne muscular dystrophy. Annals of the NY Acad Science 2009; 1175: 71-9.

Popplewell LJ, Adkin C, Arechavala-Gomeza V, Aartsma-Rus A, de Winter CL et al: Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials. Neuromuscular Disorders 2010; 20: 102-110.

 Van Putten M, Winter CL, van Roon-Mom W, van Ommen G-JB, 't Hoen PAC and Aartsma-Rus A: A mild exercise regime does not affect disease parameters in the mdx mouse. Neuromuscular Disorders 2010; 20: 273-80