Anneke A.M. Janson, Ing.

Anneke Janson was Research Technician in the DMD Genetic Therapy Group at the Human Genetics Department (LUMC) from 1999 - May 2007. She is currently working at Prosensa B.V.

Publication list

Van Deutekom, J.C., Bremmer-Bout, M., Janson, A.A., Ginjaar, I.B., Baas, F., Den Dunnen, J.T., Van Ommen, G.J. (2001) Antisense-induced exon skipping restores dystrophin expression in DMD patient derived muscle cells. Hum Mol Genet.,10,1547-1554.

Havenga, M.J., Lemckert, A.A., Ophorst, O.J., van Meijer, M., Germeraad, W.T., Grimbergen, J., van Den Doel, M.A., Vogels, R., van Deutekom, J.C., Janson, A.A., de Bruijn, J.D., Uytdehaag, F., Quax, P.H., Logtenberg, T., Mehtali, M., Bout, A. (2002) Exploiting the natural diversity in adenovirus tropism for therapy and prevention of disease. J Virol., 76, 4612-4620.

Aartsma-Rus, A., Bremmer-Bout, M., Janson, A.A., den Dunnen, J.T., van Ommen, G.J., and van Deutekom, J.C.T. (2002) Targeted antisense-induced exon skipping as a gene correction therapy for Duchenne muscular dystrophy. Neuromuscul. Disord., 12, S71-77.

Aartsma-Rus, A., Janson, A.A., Kaman, W.E., Bremmer-Bout, M., den Dunnen, J.T., Baas, F., van Ommen, G.J., and van Deutekom, J.C.T. (2003) Therapeutic antisense-induced exon skipping in muscle cells from 6 different DMD patients. Hum Mol Genet., 12, 907-914.

Aartsma-Rus, A., Janson, A.A., Kaman, W.E., Bremmer-Bout, M., van Ommen, G.J.B., den Dunnen J.T. and van Deutekom, J.C.T. (2004) Antisense-induced multi-exon skipping for DMD makes more sense. Am. J. Hum. Genet., 74, 83-92.

Aartsma-Rus, A., Kaman, W.E., Janson, A.A., Bremmer-Bout, M., den Dunnen, J.T., van Ommen, G.J.B., and van Deutekom, J.C.T. (2004) Comparative analysis of antisense oligonucleotide analogs for targeted exon skipping in muscle cells. Gene Ther.,11, 1391-1398.

Bremmer-Bout, M., Aartsma-Rus, A., de Meijer, E.J., Kaman, W., Janson, A.A., Vossen, R.H.A.M., van Ommen, GJ.B., den Dunnen, J.T., and van Deutekom, J.C.T. (2004) Targeted exon skipping in hDMD mice: a model for direct pre-clinical screening of human-specific antisense oligonucleotides. Mol Ther.,10, 232-240.

Aartsma-Rus,A., De Winter,C.L., Janson,A.A., Kaman,W.E., van Ommen,G.J., Den Dunnen,J.T., and van Deutekom,J.C. (2005) Functional analysis of 114 exon-internal AONs for targeted DMD exon skipping: indication for steric hindrance of SR protein binding sites. Oligonucleotides., 15, 284-297.

Aartsma-Rus,A., Janson,A.A., Heemskerk,J.A., De Winter,C.L., van Ommen,G.J., and van Deutekom,J.C. (2006) Therapeutic modulation of DMD splicing by blocking exonic splicing enhancer sites with antisense oligonucleotides. Ann.N.Y.Acad.Sci., 1082, 74-76.

Aartsma-Rus,A., Janson,A.A., van Ommen,G.J., and van Deutekom,J.C. (2007) Antisense-induced exon skipping for duplications in Duchenne muscular dystrophy. BMC.Med.Genet., 8, 43.

Van Deutekom, J.C.T., Janson, A.A.M., Ginjaar, H.B., Frankhuizen W.S., Aartsma-Rus, A., Bremmer-Bout, M. den Dunnen, J.T., Koop, K., van der Kooi, A.J., Goemans, N.M., de Kimpe, S.J., Ekhart, P.F., Venneker, E.H., Platenburg, G.J., Verschuuren, J.J. and van Ommen, G-J.B. (2007) Local dystrophin restoration with antisense oligonucleotide PRO051. N Engl J Med 357: 2677-86

Aartsma-Rus A, van Vliet L, Hirschi M, Janson, A.A., Heemskerk, J.A. et al. (2008) Guidelines for antisense oligonucleotide design and insight in splice modulating mechanisms. Mol Ther; in press